Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis

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Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly

Urothelial plaques consist of four major uroplakins (Ia, Ib, II, and III) that form two-dimensional crystals covering the apical surface of urothelium, and provide unique opportunities for studying membrane protein assembly. Here, we describe a novel 35-kD urothelial plaque-associated glycoprotein that is closely related to uroplakin III: they have a similar overall type 1 transmembrane topolog...

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15 صفحه اول

[Urinary BLCA-4 level is useful to detect upper urinary tract urothelial cell carcinoma].

OBJECTIVE Upper urinary tract urothelial cell carcinomas (UUT-UCCs) are rare but usually invasive at diagnosis. Early diagnosis of UUT-UCCs is thus warranted. UUT has the same embryological origin with bladder and BLCA-4 is a highly sensitive and specific marker for bladder cancer. We intend to investigate the viability of BLCA-4 in detecting UUT-UCCs. MATERIAL AND METHODS Urines from 30 UUT-...

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ژورنال

عنوان ژورنال: Kidney International

سال: 2016

ISSN: 0085-2538

DOI: 10.1016/j.kint.2015.11.017